My Bibliography

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Liu J, Liu T, Ren SV, Zhu C, Bouso E, Mamlouk S, Rau CD, Wang Y, Gao C. Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure. Front Cardiovasc Med. 2023;10:1226586. doi: 10.3389/fcvm.2023.1226586. eCollection 2023. PubMed PMID: 38188257; PubMed Central PMCID: PMC10766701.

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Huang J, Lee JZ, Rau CD, Pezhouman A, Yokota T, Miwa H, Feldman M, Kong TK, Yang Z, Tay WT, Pushkarsky I, Kim K, Parikh SS, Udani S, Soh BS, Gao C, Stiles L, Shirihai OS, Knollmann BC, Ardehali R, Di Carlo D, Wang Y. Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1. Circulation. 2023 Oct 17;148(16):1263-1266. doi: 10.1161/CIRCULATIONAHA.122.061602. Epub 2023 Oct 16. PubMed PMID: 37844148; PubMed Central PMCID: PMC10593507.

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Yu JY, Cao N, Rau CD, Lee RP, Yang J, Flach RJR, Petersen L, Zhu C, Pak YL, Miller RA, Liu Y, Wang Y, Li Z, Sun H, Gao C. Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice. Acta Pharmacol Sin. 2023 Jul;44(7):1380-1390. doi: 10.1038/s41401-023-01076-9. Epub 2023 Mar 29. PubMed PMID: 36991098; PubMed Central PMCID: PMC10310802.

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Swift SK, Purdy AL, Kolell ME, Andresen KG, Lahue C, Buddell T, Akins KA, Rau CD, O'Meara CC, Patterson M. Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds. Development. 2023 Apr 1;150(7). doi: 10.1242/dev.201318. Epub 2023 Apr 13. PubMed PMID: 36912240; PubMed Central PMCID: PMC10113957.

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Xu S, Pillai ICL, Rau CD, Wang Z. Editorial: Epigenetic regulation in cardiovascular diseases, volume II. Front Cardiovasc Med. 2023;10:1166268. doi: 10.3389/fcvm.2023.1166268. eCollection 2023. PubMed PMID: 36950284; PubMed Central PMCID: PMC10025521.

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Cao Y, Vergnes L, Wang YC, Pan C, Chella Krishnan K, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Wang Y, Vondriska TM, Reue K, Lusis AJ. Sex differences in heart mitochondria regulate diastolic dysfunction. Nat Commun. 2022 Jul 4;13(1):3850. doi: 10.1038/s41467-022-31544-5. PubMed PMID: 35787630; PubMed Central PMCID: PMC9253085.

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Pillai ICL, Xu S, Rau CD, Wang Z. Editorial: Epigenetic Regulation in Cardiovascular Diseases. Front Cardiovasc Med. 2021;8:831851. doi: 10.3389/fcvm.2021.831851. eCollection 2021. PubMed PMID: 35087888; PubMed Central PMCID: PMC8787130.

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Wang L, Wada Y, Ballan N, Schmeckpeper J, Huang J, Rau CD, Wang Y, Gepstein L, Knollmann BC. Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2021 Dec;161:130-138. doi: 10.1016/j.yjmcc.2021.08.005. Epub 2021 Aug 13. PubMed PMID: 34400182; PubMed Central PMCID: PMC9809541.

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Baranowski BJ, Allen MD, Nyarko JN, Rector RS, Padilla J, Mousseau DD, Rau CD, Wang Y, Laughlin MH, Emter CA, MacPherson RE, Olver TD. Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure. JCI Insight. 2021 May 24;6(10). doi: 10.1172/jci.insight.143141. PubMed PMID: 34027891; PubMed Central PMCID: PMC8262360.

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Kelly SC, Rau CD, Ouyang A, Thorne PK, Olver TD, Edwards JC, Domeier TL, Padilla J, Grisanti LA, Fleenor BS, Wang Y, Rector RS, Emter CA. The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature. Physiol Genomics. 2021 Mar 1;53(3):99-115. doi: 10.1152/physiolgenomics.00093.2020. Epub 2021 Jan 25. PubMed PMID: 33491589; PubMed Central PMCID: PMC7988741.

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Rau CD, Gonzales NM, Bloom JS, Park D, Ayroles J, Palmer AA, Lusis AJ, Zaitlen N. Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis". PLoS Genet. 2020 Oct;16(10):e1009165. doi: 10.1371/journal.pgen.1009165. eCollection 2020 Oct. PubMed PMID: 33104702; PubMed Central PMCID: PMC7644088.

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Yokota T, Li J, Huang J, Xiong Z, Zhang Q, Chan T, Ding Y, Rau C, Sung K, Ren S, Kulkarni R, Hsiai T, Xiao X, Touma M, Minamisawa S, Wang Y. p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart. J Clin Invest. 2020 Oct 1;130(10):5287-5301. doi: 10.1172/JCI135859. PubMed PMID: 32573492; PubMed Central PMCID: PMC7524480.

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Krebber MM, van Dijk CGM, Vernooij RWM, Brandt MM, Emter CA, Rau CD, Fledderus JO, Duncker DJ, Verhaar MC, Cheng C, Joles JA. Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling during Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis. Int J Mol Sci. 2020 Sep 14;21(18). doi: 10.3390/ijms21186742. PubMed PMID: 32937927; PubMed Central PMCID: PMC7555240.

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Rau CD, Lusis AJ, Wang Y. Systems Genetics for Mechanistic Discovery in Heart Diseases. Circ Res. 2020 Jun 5;126(12):1795-1815. doi: 10.1161/CIRCRESAHA.119.315863. Epub 2020 Jun 4. Review. PubMed PMID: 32496909; PubMed Central PMCID: PMC7286104.

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Olver TD, Edwards JC, Jurrissen TJ, Veteto AB, Jones JL, Gao C, Rau C, Warren CM, Klutho PJ, Alex L, Ferreira-Nichols SC, Ivey JR, Thorne PK, McDonald KS, Krenz M, Baines CP, Solaro RJ, Wang Y, Ford DA, Domeier TL, Padilla J, Rector RS, Emter CA. Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. JACC Basic Transl Sci. 2019 Jun;4(3):404-421. doi: 10.1016/j.jacbts.2019.02.004. eCollection 2019 Jun. PubMed PMID: 31312763; PubMed Central PMCID: PMC6610000.

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Tzimas C, Rau CD, Buergisser PE, Jean-Louis G Jr, Lee K, Chukwuneke J, Dun W, Wang Y, Tsai EJ. WIPI1 is a conserved mediator of right ventricular failure. JCI Insight. 2019 Apr 25;5(11). doi: 10.1172/jci.insight.122929. PubMed PMID: 31021818; PubMed Central PMCID: PMC6629151.

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Lin LY, Chun Chang S, O'Hearn J, Hui ST, Seldin M, Gupta P, Bondar G, Deng M, Jauhiainen R, Kuusisto J, Laakso M, Sinsheimer JS, Deb A, Rau C, Ren S, Wang Y, Lusis AJ, Wang JJ, Huertas-Vazquez A. Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans. G3 (Bethesda). 2018 Nov 6;8(11):3499-3506. doi: 10.1534/g3.118.200655. PubMed PMID: 30201759; PubMed Central PMCID: PMC6222577.

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Park S, Ranjbarvaziri S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Rau C, Wang Y, Mikkola HKA, Lusis AJ, Ardehali R. Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Circulation. 2018 Sep 18;138(12):1224-1235. doi: 10.1161/CIRCULATIONAHA.118.035420. PubMed PMID: 29950403; PubMed Central PMCID: PMC6202226.

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Santolini M, Romay MC, Yukhtman CL, Rau CD, Ren S, Saucerman JJ, Wang JJ, Weiss JN, Wang Y, Lusis AJ, Karma A. A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure. NPJ Syst Biol Appl. 2018;4:12. doi: 10.1038/s41540-018-0046-3. eCollection 2018. PubMed PMID: 29507758; PubMed Central PMCID: PMC5825397.

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Chang SC, Ren S, Rau CD, Wang JJ. Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation. Methods Mol Biol. 2018;1816:207-220. doi: 10.1007/978-1-4939-8597-5_16. PubMed PMID: 29987822; PubMed Central PMCID: PMC6445258.

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Rau CD, Vondriska TM. DNA Methylation and Human Heart Failure: Mechanisms or Prognostics. Circulation. 2017 Oct 17;136(16):1545-1547. doi: 10.1161/CIRCULATIONAHA.117.029840. PubMed PMID: 29038208; PubMed Central PMCID: PMC5683409.

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Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JG, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov HM. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep;49(9):1346-1353. doi: 10.1038/ng.3929. Epub 2017 Aug 7. PubMed PMID: 28783163; PubMed Central PMCID: PMC5736145.

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Wisniewski N, Bondar G, Rau C, Chittoor J, Chang E, Esmaeili A, Cadeiras M, Deng M. Integrative model of leukocyte genomics and organ dysfunction in heart failure patients requiring mechanical circulatory support: a prospective observational study. BMC Med Genomics. 2017 Aug 29;10(1):52. doi: 10.1186/s12920-017-0288-8. PubMed PMID: 28851355; PubMed Central PMCID: PMC5576384.

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Gao C, Howard-Quijano K, Rau C, Takamiya T, Song Y, Shivkumar K, Wang Y, Mahajan A. Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction. PLoS One. 2017;12(5):e0177750. doi: 10.1371/journal.pone.0177750. eCollection 2017. PubMed PMID: 28542617; PubMed Central PMCID: PMC5436752.

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Seldin MM, Kim ED, Romay MC, Li S, Rau CD, Wang JJ, Krishnan KC, Wang Y, Deb A, Lusis AJ. A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H728-H741. doi: 10.1152/ajpheart.00068.2016. Epub 2017 Feb 24. PubMed PMID: 28235788; PubMed Central PMCID: PMC5407157.

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Rau CD, Romay MC, Tuteryan M, Wang JJ, Santolini M, Ren S, Karma A, Weiss JN, Wang Y, Lusis AJ. Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. Cell Syst. 2017 Jan 25;4(1):121-128.e4. doi: 10.1016/j.cels.2016.10.016. Epub 2016 Nov 17. PubMed PMID: 27866946; PubMed Central PMCID: PMC5338604.

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Rau CD, Civelek M, Pan C, Lusis AJ. A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel. Methods Mol Biol. 2017;1488:153-188. doi: 10.1007/978-1-4939-6427-7_7. PubMed PMID: 27933524; PubMed Central PMCID: PMC6615944.

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Rau CD, Gao C, Wang Y. Deconvolution of the Human Endothelial Transcriptome. Cell Syst. 2016 Sep 28;3(3):218-220. doi: 10.1016/j.cels.2016.09.006. PubMed PMID: 27684186; PubMed Central PMCID: PMC5394198.

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Karbassi E, Monte E, Chapski DJ, Lopez R, Rosa Garrido M, Kim J, Wisniewski N, Rau CD, Wang JJ, Weiss JN, Wang Y, Lusis AJ, Vondriska TM. Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation. Physiol Genomics. 2016 Aug 1;48(8):601-15. doi: 10.1152/physiolgenomics.00035.2016. Epub 2016 Jun 10. PubMed PMID: 27287924; PubMed Central PMCID: PMC5005461.

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Monte E, Rosa-Garrido M, Karbassi E, Chen H, Lopez R, Rau CD, Wang J, Nelson SF, Wu Y, Stefani E, Lusis AJ, Wang Y, Kurdistani SK, Franklin S, Vondriska TM. Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. J Biol Chem. 2016 Jul 22;291(30):15428-46. doi: 10.1074/jbc.M116.719633. Epub 2016 May 16. PubMed PMID: 27226577; PubMed Central PMCID: PMC4957031.

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Wang JJ, Rau C, Avetisyan R, Ren S, Romay MC, Stolin G, Gong KW, Wang Y, Lusis AJ. Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS Genet. 2016 Jul;12(7):e1006038. doi: 10.1371/journal.pgen.1006038. eCollection 2016 Jul. PubMed PMID: 27385019; PubMed Central PMCID: PMC4934852.

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Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 Jun;57(6):925-42. doi: 10.1194/jlr.R066944. Epub 2016 Apr 19. Review. PubMed PMID: 27099397; PubMed Central PMCID: PMC4878195.

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Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. 2016 May 24;133(21):2038-49. doi: 10.1161/CIRCULATIONAHA.115.020226. Epub 2016 Apr 8. PubMed PMID: 27059949; PubMed Central PMCID: PMC4879058.

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Chen H, Orozco LD, Wang J, Rau CD, Rubbi L, Ren S, Wang Y, Pellegrini M, Lusis AJ, Vondriska TM. DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. Circ Res. 2016 Mar 4;118(5):786-97. doi: 10.1161/CIRCRESAHA.115.305298. Epub 2016 Jan 11. PubMed PMID: 26838786; PubMed Central PMCID: PMC4779427.

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Gao C, Ren S, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, Xiao X, Fu XD, Chen JN, Wang Y. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. J Clin Invest. 2016 Jan;126(1):195-206. doi: 10.1172/JCI84015. Epub 2015 Nov 30. PubMed PMID: 26619120; PubMed Central PMCID: PMC4701548.

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Neelankavil J, Rau CD, Wang Y. The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets. J Cardiothorac Vasc Anesth. 2015 Oct;29(5):1328-32. doi: 10.1053/j.jvca.2015.01.031. Epub 2015 Jan 23. Review. PubMed PMID: 25976605; PubMed Central PMCID: PMC4539278.

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Rau CD, Parks B, Wang Y, Eskin E, Simecek P, Churchill GA, Lusis AJ. High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. G3 (Bethesda). 2015 Jul 28;5(10):2021-6. doi: 10.1534/g3.115.020784. PubMed PMID: 26224782; PubMed Central PMCID: PMC4592984.

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Rau CD, Lusis AJ, Wang Y. Genetics of common forms of heart failure: challenges and potential solutions. Curr Opin Cardiol. 2015 May;30(3):222-7. doi: 10.1097/HCO.0000000000000160. Review. PubMed PMID: 25768955; PubMed Central PMCID: PMC4406340.

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Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ. Genetic architecture of insulin resistance in the mouse. Cell Metab. 2015 Feb 3;21(2):334-347. doi: 10.1016/j.cmet.2015.01.002. PubMed PMID: 25651185; PubMed Central PMCID: PMC4349439.

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Rau CD, Wang J, Avetisyan R, Romay MC, Martin L, Ren S, Wang Y, Lusis AJ. Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. Circ Cardiovasc Genet. 2015 Feb;8(1):40-9. doi: 10.1161/CIRCGENETICS.113.000732. Epub 2014 Dec 5. PubMed PMID: 25480693; PubMed Central PMCID: PMC4334708.

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Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, Wang Y. PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab. 2013;2(4):405-16. doi: 10.1016/j.molmet.2013.07.005. eCollection 2013. PubMed PMID: 24327956; PubMed Central PMCID: PMC3854994.

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Lagarrigue S, Hormozdiari F, Martin LJ, Lecerf F, Hasin Y, Rau C, Hagopian R, Xiao Y, Yan J, Drake TA, Ghazalpour A, Eskin E, Lusis AJ. Limited RNA editing in exons of mouse liver and adipose. Genetics. 2013 Apr;193(4):1107-15. doi: 10.1534/genetics.112.149054. Epub 2013 Feb 14. PubMed PMID: 23410828; PubMed Central PMCID: PMC3606090.

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Davis RC, van Nas A, Bennett B, Orozco L, Pan C, Rau CD, Eskin E, Lusis AJ. Genome-wide association mapping of blood cell traits in mice. Mamm Genome. 2013 Apr;24(3-4):105-18. doi: 10.1007/s00335-013-9448-0. Epub 2013 Feb 17. PubMed PMID: 23417284; PubMed Central PMCID: PMC3933005.

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Rau CD, Wisniewski N, Orozco LD, Bennett B, Weiss J, Lusis AJ. Maximal information component analysis: a novel non-linear network analysis method. Front Genet. 2013;4:28. doi: 10.3389/fgene.2013.00028. eCollection 2013. PubMed PMID: 23487572; PubMed Central PMCID: PMC3594742.

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Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis AJ. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 2013 Jan 8;17(1):141-52. doi: 10.1016/j.cmet.2012.12.007. PubMed PMID: 23312289; PubMed Central PMCID: PMC3545283.

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Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct;23(9-10):680-92. doi: 10.1007/s00335-012-9411-5. Epub 2012 Aug 15. Review. PubMed PMID: 22892838; PubMed Central PMCID: PMC3586763.

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Weiss JN, Karma A, MacLellan WR, Deng M, Rau CD, Rees CM, Wang J, Wisniewski N, Eskin E, Horvath S, Qu Z, Wang Y, Lusis AJ. "Good enough solutions" and the genetics of complex diseases. Circ Res. 2012 Aug 3;111(4):493-504. doi: 10.1161/CIRCRESAHA.112.269084. Review. PubMed PMID: 22859671; PubMed Central PMCID: PMC3428228.

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Mungrue IN, Zhao P, Yao Y, Meng H, Rau C, Havel JV, Gorgels TG, Bergen AA, MacLellan WR, Drake TA, Boström KI, Lusis AJ. Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2806-12. doi: 10.1161/ATVBAHA.111.237420. Epub 2011 Oct 6. PubMed PMID: 21979437; PubMed Central PMCID: PMC3227394.

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Ho MC, Johnsen H, Goetz SE, Schiller BJ, Bae E, Tran DA, Shur AS, Allen JM, Rau C, Bender W, Fisher WW, Celniker SE, Drewell RA. Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila. PLoS Genet. 2009 Nov;5(11):e1000709. doi: 10.1371/journal.pgen.1000709. Epub 2009 Nov 6. PubMed PMID: 19893611; PubMed Central PMCID: PMC2763271.