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Mikami Y, Grubb BR, Rogers TD, Dang H, Asakura T, Kota P, Gilmore RC, Okuda K, Morton LC, Sun L, Chen G, Wykoff JA, Ehre C, Vilar J, van Heusden C, Livraghi-Butrico A, Gentzsch M, Button B, Stutts MJ, Randell SH, O'Neal WK, Boucher RC. Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration. Sci Transl Med. 2023 Jun 7;15(699):eabo7728. doi: 10.1126/scitranslmed.abo7728. Epub 2023 Jun 7. PubMed PMID: 37285404; PubMed Central PMCID: PMC10664029.
Hill DB, Button B, Rubinstein M, Boucher RC. Physiology and pathophysiology of human airway mucus. Physiol Rev. 2022 Oct 1;102(4):1757-1836. doi: 10.1152/physrev.00004.2021. Epub 2022 Jan 10. Review. PubMed PMID: 35001665; PubMed Central PMCID: PMC9665957.
Figueira MF, Ribeiro CMP, Button B. Mucus-targeting therapies of defective mucus clearance for cystic fibrosis: A short review. Curr Opin Pharmacol. 2022 Aug;65:102248. doi: 10.1016/j.coph.2022.102248. Epub 2022 Jun 8. Review. PubMed PMID: 35689870; PubMed Central PMCID: PMC9891491.
Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. Nat Genet. 2022 Aug;54(8):1078-1089. doi: 10.1038/s41588-022-01131-x. Epub 2022 Jul 25. PubMed PMID: 35879412; PubMed Central PMCID: PMC9355872.
Kato T, Radicioni G, Papanikolas MJ, Stoychev GV, Markovetz MR, Aoki K, Porterfield M, Okuda K, Barbosa Cardenas SM, Gilmore RC, Morrison CB, Ehre C, Burns KA, White KK, Brennan TA, Goodell HP, Thacker H, Loznev HT, Forsberg LJ, Nagase T, Rubinstein M, Randell SH, Tiemeyer M, Hill DB, Kesimer M, O'Neal WK, Ballard ST, Freeman R, Button B, Boucher RC. Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis. Sci Adv. 2022 Apr;8(13):eabm9718. doi: 10.1126/sciadv.abm9718. Epub 2022 Apr 1. PubMed PMID: 35363522; PubMed Central PMCID: PMC10938572.
Rogers TD, Button B, Kelada SNP, Ostrowski LE, Livraghi-Butrico A, Gutay MI, Esther CR Jr, Grubb BR. Regional Differences in Mucociliary Clearance in the Upper and Lower Airways. Front Physiol. 2022;13:842592. doi: 10.3389/fphys.2022.842592. eCollection 2022. PubMed PMID: 35356083; PubMed Central PMCID: PMC8959816.
Dahl DK, Whitesell AN, Sharma-Huynh P, Maturavongsadit P, Janusziewicz R, Fox RJ, Loznev HT, Button B, Schorzman AN, Zamboni W, Ban J, Montgomery SA, Carey ET, Rahima Benhabbour S. A mucoadhesive biodissolvable thin film for localized and rapid delivery of lidocaine for the treatment of vestibulodynia. Int J Pharm. 2022 Jan 25;612:121288. doi: 10.1016/j.ijpharm.2021.121288. Epub 2021 Nov 17. PubMed PMID: 34800616; PubMed Central PMCID: PMC8753993.
van Heusden C, Grubb BR, Button B, Lazarowski ER. Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance. Life (Basel). 2021 May 11;11(5). doi: 10.3390/life11050430. Review. PubMed PMID: 34064654; PubMed Central PMCID: PMC8151306.
Bennett WD, Henderson AG, Ceppe A, Zeman KL, Wu J, Gladman C, Fuller F, Gazda S, Button B, Boucher RC, Donaldson SH. Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis. ERJ Open Res. 2020 Jul;6(3). doi: 10.1183/23120541.00269-2020. eCollection 2020 Jul. PubMed PMID: 32802823; PubMed Central PMCID: PMC7418818.
Danahay HL, Lilley S, Fox R, Charlton H, Sabater J, Button B, McCarthy C, Collingwood SP, Gosling M. TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. Am J Respir Crit Care Med. 2020 Apr 15;201(8):946-954. doi: 10.1164/rccm.201908-1641OC. PubMed PMID: 31898911; PubMed Central PMCID: PMC7159426.
Ramsey KA, Chen ACH, Radicioni G, Lourie R, Martin M, Broomfield A, Sheng YH, Hasnain SZ, Radford-Smith G, Simms LA, Burr L, Thornton DJ, Bowler SD, Livengood S, Ceppe A, Knowles MR, Noone PG Sr, Donaldson SH, Hill DB, Ehre C, Button B, Alexis NE, Kesimer M, Boucher RC, McGuckin MA. Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis. Am J Respir Crit Care Med. 2020 Mar 15;201(6):661-670. doi: 10.1164/rccm.201906-1219OC. PubMed PMID: 31765597; PubMed Central PMCID: PMC7068838.
van Heusden C, Button B, Anderson WH, Ceppe A, Morton LC, O'Neal WK, Dang H, Alexis NE, Donaldson S, Stephan H, Boucher RC, Lazarowski ER. Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L356-L365. doi: 10.1152/ajplung.00449.2019. Epub 2019 Dec 4. PubMed PMID: 31800264; PubMed Central PMCID: PMC7052677.
Chen G, Sun L, Kato T, Okuda K, Martino MB, Abzhanova A, Lin JM, Gilmore RC, Batson BD, O'Neal YK, Volmer AS, Dang H, Deng Y, Randell SH, Button B, Livraghi-Butrico A, Kesimer M, Ribeiro CM, O'Neal WK, Boucher RC. IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis. J Clin Invest. 2019 Oct 1;129(10):4433-4450. doi: 10.1172/JCI125669. PubMed PMID: 31524632; PubMed Central PMCID: PMC6763234.
Goodell HP, Shenoy SK, Shenkute NT, Lackey E, Dennis RG, Button B. Adhesive and Cohesive Peel Force Measurement of Human Airway Mucus. Bio Protoc. 2019 Jul 5;9(13). doi: 10.21769/BioProtoc.3287. PubMed PMID: 31687423; PubMed Central PMCID: PMC6827558.
Hill DB, Long RF, Kissner WJ, Atieh E, Garbarine IC, Markovetz MR, Fontana NC, Christy M, Habibpour M, Tarran R, Forest MG, Boucher RC, Button B. Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH. Eur Respir J. 2018 Dec;52(6). doi: 10.1183/13993003.01297-2018. Print 2018 Dec. PubMed PMID: 30361244; PubMed Central PMCID: PMC6446239.
Button B, Goodell HP, Atieh E, Chen YC, Williams R, Shenoy S, Lackey E, Shenkute NT, Cai LH, Dennis RG, Boucher RC, Rubinstein M. Roles of mucus adhesion and cohesion in cough clearance. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12501-12506. doi: 10.1073/pnas.1811787115. Epub 2018 Nov 12. PubMed PMID: 30420506; PubMed Central PMCID: PMC6298066.
Goralski JL, Wu D, Thelin WR, Boucher RC, Button B. The in vitro effect of nebulised hypertonic saline on human bronchial epithelium. Eur Respir J. 2018 May;51(5). doi: 10.1183/13993003.02652-2017. Print 2018 May. PubMed PMID: 29599187; PubMed Central PMCID: PMC6000726.
Wu D, Boucher RC, Button B, Elston T, Lin CL. An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces. J Theor Biol. 2018 Feb 7;438:34-45. doi: 10.1016/j.jtbi.2017.11.010. Epub 2017 Nov 15. PubMed PMID: 29154907; PubMed Central PMCID: PMC5764545.
Schultz A, Puvvadi R, Borisov SM, Shaw NC, Klimant I, Berry LJ, Montgomery ST, Nguyen T, Kreda SM, Kicic A, Noble PB, Button B, Stick SM. Airway surface liquid pH is not acidic in children with cystic fibrosis. Nat Commun. 2017 Nov 10;8(1):1409. doi: 10.1038/s41467-017-00532-5. PubMed PMID: 29123085; PubMed Central PMCID: PMC5680186.
Esther CR Jr, Hill DB, Button B, Shi S, Jania C, Duncan EA, Doerschuk CM, Chen G, Ranganathan S, Stick SM, Boucher RC. Sialic acid-to-urea ratio as a measure of airway surface hydration. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L398-L404. doi: 10.1152/ajplung.00398.2016. Epub 2017 Jan 6. PubMed PMID: 28062483; PubMed Central PMCID: PMC5374301.
Grubb BR, Livraghi-Butrico A, Rogers TD, Yin W, Button B, Ostrowski LE. Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin. Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9):L860-7. doi: 10.1152/ajplung.00015.2016. Epub 2016 Mar 11. PubMed PMID: 26968767; PubMed Central PMCID: PMC4867354.
Button B, Anderson WH, Boucher RC. Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype. Ann Am Thorac Soc. 2016 Apr;13 Suppl 2(Suppl 2):S156-62. doi: 10.1513/AnnalsATS.201507-455KV. Review. PubMed PMID: 27115951; PubMed Central PMCID: PMC5015722.
Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC. The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis. Am J Respir Crit Care Med. 2015 Jul 15;192(2):182-90. doi: 10.1164/rccm.201412-2230OC. PubMed PMID: 25909230; PubMed Central PMCID: PMC4532825.
Chhetri RK, Blackmon RL, Wu WC, Hill DB, Button B, Casbas-Hernandez P, Troester MA, Tracy JB, Oldenburg AL. Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4289-97. doi: 10.1073/pnas.1409321111. Epub 2014 Sep 29. PubMed PMID: 25267619; PubMed Central PMCID: PMC4205670.
Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. J Clin Invest. 2014 Jul;124(7):3047-60. doi: 10.1172/JCI73469. Epub 2014 Jun 2. PubMed PMID: 24892808; PubMed Central PMCID: PMC4072023.
Button BM, Button B. Structure and function of the mucus clearance system of the lung. Cold Spring Harb Perspect Med. 2013 Aug 1;3(8). doi: 10.1101/cshperspect.a009720. Review. PubMed PMID: 23751214; PubMed Central PMCID: PMC3721269.
Button B, Okada SF, Frederick CB, Thelin WR, Boucher RC. Mechanosensitive ATP release maintains proper mucus hydration of airways. Sci Signal. 2013 Jun 11;6(279):ra46. doi: 10.1126/scisignal.2003755. PubMed PMID: 23757023; PubMed Central PMCID: PMC3791865.
Herschlag G, Garcia GJ, Button B, Tarran R, Lindley B, Reinhardt B, Elston TC, Forest MG. A mechanochemical model for auto-regulation of lung airway surface layer volume. J Theor Biol. 2013 May 21;325:42-51. doi: 10.1016/j.jtbi.2013.01.023. Epub 2013 Feb 13. PubMed PMID: 23415939; PubMed Central PMCID: PMC3631568.
Oldenburg AL, Chhetri RK, Hill DB, Button B. Monitoring airway mucus flow and ciliary activity with optical coherence tomography. Biomed Opt Express. 2012 Sep 1;3(9):1978-92. doi: 10.1364/BOE.3.001978. Epub 2012 Aug 1. PubMed PMID: 23024894; PubMed Central PMCID: PMC3447542.
Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science. 2012 Aug 24;337(6097):937-41. doi: 10.1126/science.1223012. PubMed PMID: 22923574; PubMed Central PMCID: PMC3633213.
Hill DB, Button B. Establishment of respiratory air-liquid interface cultures and their use in studying mucin production, secretion, and function. Methods Mol Biol. 2012;842:245-58. doi: 10.1007/978-1-61779-513-8_15. PubMed PMID: 22259141.
Garcia GJ, Picher M, Zuo P, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC. Computational model for the regulation of extracellular ATP and adenosine in airway epithelia. Subcell Biochem. 2011;55:51-74. doi: 10.1007/978-94-007-1217-1_3. Review. PubMed PMID: 21560044.
Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. J Biol Chem. 2010 Aug 27;285(35):26945-26955. doi: 10.1074/jbc.M110.151803. Epub 2010 Jun 21. PubMed PMID: 20566636; PubMed Central PMCID: PMC2930694.
Goralski JL, Boucher RC, Button B. Osmolytes and ion transport modulators: new strategies for airway surface rehydration. Curr Opin Pharmacol. 2010 Jun;10(3):294-9. doi: 10.1016/j.coph.2010.04.003. Epub 2010 May 1. Review. PubMed PMID: 20439165; PubMed Central PMCID: PMC8855330.
Zhang L, Button B, Gabriel SE, Burkett S, Yan Y, Skiadopoulos MH, Dang YL, Vogel LN, McKay T, Mengos A, Boucher RC, Collins PL, Pickles RJ. CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium. PLoS Biol. 2009 Jul;7(7):e1000155. doi: 10.1371/journal.pbio.1000155. Epub 2009 Jul 21. PubMed PMID: 19621064; PubMed Central PMCID: PMC2705187.
Button B, Boucher RC. Role of mechanical stress in regulating airway surface hydration and mucus clearance rates. Respir Physiol Neurobiol. 2008 Nov 30;163(1-3):189-201. doi: 10.1016/j.resp.2008.04.020. Epub 2008 Jun 8. Review. PubMed PMID: 18585484; PubMed Central PMCID: PMC2645865.
Zuo P, Picher M, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC. Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis. J Biol Chem. 2008 Sep 26;283(39):26805-19. doi: 10.1074/jbc.M801516200. Epub 2008 Jul 28. PubMed PMID: 18662982; PubMed Central PMCID: PMC2546543.
Button B, Picher M, Boucher RC. Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia. J Physiol. 2007 Apr 15;580(Pt. 2):577-92. doi: 10.1113/jphysiol.2006.126086. Epub 2007 Feb 22. PubMed PMID: 17317749; PubMed Central PMCID: PMC2075559.
Matsui H, Wagner VE, Hill DB, Schwab UE, Rogers TD, Button B, Taylor RM 2nd, Superfine R, Rubinstein M, Iglewski BH, Boucher RC. A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18131-6. doi: 10.1073/pnas.0606428103. Epub 2006 Nov 20. PubMed PMID: 17116883; PubMed Central PMCID: PMC1838718.
Tarran R, Button B, Boucher RC. Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress. Annu Rev Physiol. 2006;68:543-61. doi: 10.1146/annurev.physiol.68.072304.112754. Review. PubMed PMID: 16460283.
Koukoulis G, Caldwell R, Inokawa H, Button B, Sevala M, Lyles JD, Takashima S, Blackwell J, Randell SH, Egan TM. Trends in lung pH and PO2 after circulatory arrest: implications for non-heart-beating donors and cell culture models of lung ischemia-reperfusion injury. J Heart Lung Transplant. 2005 Dec;24(12):2218-25. doi: 10.1016/j.healun.2005.06.009. Epub 2005 Nov 17. PubMed PMID: 16364874.
Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC. Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. J Biol Chem. 2005 Oct 21;280(42):35751-9. doi: 10.1074/jbc.M505832200. Epub 2005 Aug 8. PubMed PMID: 16087672; PubMed Central PMCID: PMC2924153.
Chen Y, Button B, Altenberg GA, Reuss L. Potentiation of effect of PKA stimulation of Xenopus CFTR by activation of PKC: role of NBD2. Am J Physiol Cell Physiol. 2004 Nov;287(5):C1436-44. doi: 10.1152/ajpcell.00045.2004. Epub 2004 Jul 28. PubMed PMID: 15282191.
Roomans GM, Kozlova I, Nilsson H, Vanthanouvong V, Button B, Tarran R. Measurements of airway surface liquid height and mucus transport by fluorescence microscopy, and of ion composition by X-ray microanalysis. J Cyst Fibros. 2004 Aug;3 Suppl 2:135-9. doi: 10.1016/j.jcf.2004.05.029. PubMed PMID: 15463946.
Button B, Reuss L, Altenberg GA. PKC-mediated stimulation of amphibian CFTR depends on a single phosphorylation consensus site. insertion of this site confers PKC sensitivity to human CFTR. J Gen Physiol. 2001 May;117(5):457-68. doi: 10.1085/jgp.117.5.457. PubMed PMID: 11331356; PubMed Central PMCID: PMC2233655.
Button B, Baker RD, Vertrees RA, Allen SE, Brodwick MS, Kramer GC. Quantitative assessment of a circulating depolarizing factor in shock. Shock. 2001 Mar;15(3):239-44. doi: 10.1097/00024382-200115030-00013. PubMed PMID: 11236909.
Kinsky MP, Milner SM, Button B, Dubick MA, Kramer GC. Resuscitation of severe thermal injury with hypertonic saline dextran: effects on peripheral and visceral edema in sheep. J Trauma. 2000 Nov;49(5):844-53. doi: 10.1097/00005373-200011000-00009. PubMed PMID: 11086774.
Kinsky MP, Guha SC, Button BM, Kramer GC. The role of interstitial starling forces in the pathogenesis of burn edema. J Burn Care Rehabil. 1998 Jan-Feb;19(1 Pt 1):1-9. doi: 10.1097/00004630-199801000-00004. PubMed PMID: 9502017.
Guha SC, Kinsky MP, Button B, Herndon DN, Traber LD, Traber DL, Kramer GC. Burn resuscitation: crystalloid versus colloid versus hypertonic saline hyperoncotic colloid in sheep. Crit Care Med. 1996 Nov;24(11):1849-57. doi: 10.1097/00003246-199611000-00015. PubMed PMID: 8917036.
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