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2022 Dec 1;206(11):1336-1352. doi: 10.1164/rccm.202111-2606OC. PubMed PMID:
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Immunogenetics associated with severe coccidioidomycosis.
JCI Insight.
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Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.
Am J Respir Crit Care Med.
2021 May 15;203(10):1275-1289. doi: 10.1164/rccm.202008-3198OC. PubMed PMID:
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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Cell.
2020 Jul 23;182(2):429-446.e14. doi: 10.1016/j.cell.2020.05.042. Epub 2020 May 27. PubMed PMID:
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IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis.
J Clin Invest.
2019 Oct 1;129(10):4433-4450. doi: 10.1172/JCI125669. PubMed PMID:
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XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.
Am J Respir Crit Care Med.
2019 Jul 15;200(2):220-234. doi: 10.1164/rccm.201810-1972OC. PubMed PMID:
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Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.
Am J Respir Crit Care Med.
2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC. PubMed PMID:
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Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice.
Am J Respir Cell Mol Biol.
2018 Sep;59(3):383-396. doi: 10.1165/rcmb.2017-0127OC. PubMed PMID:
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Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.
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Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1.
Genetics.
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Sialic acid-to-urea ratio as a measure of airway surface hydration.
Am J Physiol Lung Cell Mol Physiol.
2017 Mar 1;312(3):L398-L404. doi: 10.1152/ajplung.00398.2016. Epub 2017 Jan 6. PubMed PMID:
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Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.
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Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.
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Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.
Am J Pathol.
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SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.
Gastroenterology.
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FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.
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SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia.
Proc Natl Acad Sci U S A.
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Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium.
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Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.
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Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation.
Proc Natl Acad Sci U S A.
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Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.
J Immunol.
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SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
J Clin Invest.
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CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.
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SPDEF regulates goblet cell hyperplasia in the airway epithelium.
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